Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.7K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

13.5K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.5K
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

192
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
192
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

781
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
781
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

226
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
226

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Multilevel and Multidomain Interventions on Glycemic Control Among Black Persons with Type 2 Diabetes in the U.S.: A Systematic Review and Meta-Analysis.

Journal of racial and ethnic health disparities·2026
Same author

Effectiveness of Interventions to Improve Glycemic Control in US Asian and Pacific Islander Populations With Type 2 Diabetes: Systematic Review and Meta-Analysis.

Asian/Pacific Island nursing journal·2026
Same author

Evaluation of a Clinic-Level Intervention to Increase Anxiety and Depression Screening in an Urban HIV Clinic.

AIDS and behavior·2026
Same author

Suboptimal Levothyroxine Treatment is Associated with Increases in Mean Blood Pressure and Blood Pressure Variability.

The Journal of clinical endocrinology and metabolism·2025
Same author

Adolescents as co-designers: adapting human-centered design to develop school-based mental health strategies in northern Ghana.

BMC public health·2025
Same author

Primary Care Clinician Perspectives on Older Adult Chronic Pain Management and Clinical Decision Support: Qualitative Study.

JMIR formative research·2025

Related Experiment Video

Updated: Dec 21, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.2K

Economic Simulation Modeling in Type 2 Diabetes.

Rahul S Dadwani1, Neda Laiteerapong2

  • 1Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.

Current Diabetes Reports
|May 19, 2020
PubMed
Summary
This summary is machine-generated.

Economic simulation models for type 2 diabetes have advanced significantly, improving comparability. Future research should focus on racial/ethnic minority progression and health equity in economic analyses.

Keywords:
Cost-effectivenessEconomic simulation modelingHealth economic analysisMount Hood Diabetes ChallengeType 2 diabetes

More Related Videos

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

9.9K
Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

894

Related Experiment Videos

Last Updated: Dec 21, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.2K
Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

9.9K
Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

894

Area of Science:

  • Health economics
  • Epidemiological modeling
  • Type 2 Diabetes Mellitus

Background:

  • Economic simulation models are crucial for understanding type 2 diabetes (T2DM) interventions.
  • The field faces challenges in model generalizability and reporting transparency.
  • Standardization efforts are underway to enhance model comparability.

Purpose of the Study:

  • To provide an overview of T2DM economic simulation modeling.
  • To review current discussions and major challenges in the field.
  • To highlight advancements driven by collaborative initiatives.

Main Methods:

  • Review of current literature and ongoing discussions in T2DM economic modeling.
  • Analysis of challenges related to model generalizability and transparency.
  • Examination of tools and methodologies developed through collaborative efforts like the Mount Hood Diabetes Challenge.

Main Results:

  • Significant improvements in T2DM simulation models over two decades, attributed to collaborative work.
  • Development and adoption of standardization tools (checklist, impact inventory) enhancing model comparability.
  • Identification of key challenges including generalizability, transparency, and the need for equity considerations.

Conclusions:

  • Collaborative efforts have substantially improved T2DM economic models.
  • Future research must address diabetes progression in minority populations.
  • Incorporating equity into health economic analyses is essential for advancing the field.