Bioglass-based scaffolds coated with silver nanoparticles: Synthesis, processing and antimicrobial activity
Rodrigo L M S Oliveira1, Lucas Barbosa1, Carolina R Hurtado2,3
1Bioceramics Laboratory, Science and Technology Institute, UNIFESP, São José dos Campos, SP, Brazil.
Journal of Biomedical Materials Research. Part A
|May 19, 2020
Summary
Silver nanoparticles were successfully coated onto 45S5 bioglass bone scaffolds using ultrasonic stirring. The resulting glass-ceramic scaffolds demonstrated effective antimicrobial activity against common microbial strains.
Area of Science:
- Biomaterials Science
- Materials Engineering
- Nanotechnology
Background:
- Synthetic bone grafts (scaffolds) are developed to overcome limitations of autologous grafts.
- 45S5 bioglass is a promising scaffold material due to its tissue bonding capabilities.
- Incorporating silver nanoparticles (AgNPs) can impart antimicrobial properties to scaffolds.
Purpose of the Study:
- To develop a simple method for coating 45S5 bioglass scaffolds with silver nanoparticles.
- To evaluate the antimicrobial efficacy of AgNP-coated bioglass scaffolds.
Main Methods:
- Scaffolds were fabricated using the sponge replication technique.
- Silver nanoparticles were coated onto the bioglass scaffolds via soaking with ultrasonic stirring.
- Antimicrobial activity was tested against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans.
Main Results:
- The bioglass crystallized into a sodium calcium silicate phase, forming a glass-ceramic scaffold.
- Silver nanoparticles were uniformly distributed on the scaffold without aggregation.
- The AgNP-coated scaffold effectively inhibited the growth of all tested microorganisms.
Conclusions:
- Ultrasonic stirring is an efficient method for coating bioglass scaffolds with silver nanoparticles.
- AgNP-coated bioglass scaffolds exhibit significant antimicrobial properties.
- This approach offers a promising strategy for developing infection-resistant bone graft materials.
