Calcium regulation of stem cells
Hans-Willem Snoeck1,2,3,4
1Columbia Center of Human Development, Columbia University Irving Medical Center, New York, NY, USA.
EMBO Reports
|May 19, 2020
Summary
Calcium signaling plays a key role in maintaining stem cell identity and function. This review explores calcium
Area of Science:
- Stem cell biology
- Cell signaling
- Epigenetics
- Metabolism
Background:
- Pluripotent and tissue-specific stem cells share self-renewal and differentiation capacities.
- Stem cell identity is maintained by specific transcriptional and epigenetic mechanisms.
- Calcium acts as a ubiquitous second messenger regulating diverse cellular functions.
Purpose of the Study:
- To review the specific roles and regulation of calcium in stem cell niches.
- To explore calcium's involvement in stem cell maintenance mechanisms.
- To discuss the interplay between calcium, metabolism, and epigenetics in stem cells.
Main Methods:
- Literature review of existing research on calcium and stem cells.
- Analysis of studies investigating calcium's role in stem cell differentiation and self-renewal.
- Examination of the link between calcium signaling, metabolic pathways, and epigenetic modifications.
Main Results:
- Calcium signaling is crucial for various stem cell functions.
- Stem cell-specific calcium regulation mechanisms are emerging.
- Calcium influences stem cell identity through metabolic and epigenetic crosstalk.
Conclusions:
- Calcium is a critical regulator of stem cell maintenance and identity.
- Further research into calcium's role in stem cell niches is warranted.
- Targeting calcium pathways may offer new strategies for stem cell therapies.
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