Related Experiment Video
Updated: Dec 21, 2025
08:44
Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
Published on: September 7, 2022
2.8K
Clinically isolated syndrome and multiple sclerosis in children: a single center study
Gonca Bektaş1, Melis Ulak Özkan2, Edibe Pembegül Yıldız2
1Department of Pediatric Neurology, Bakırköy Dr. Sadi Konuk Research and Training Hospital, İstanbul.
The Turkish Journal of Pediatrics
|May 19, 2020
Summary
Older age at first demyelination and specific MRI findings like more T2 lesions in certain brain areas predict the development of multiple sclerosis (MS) in children initially diagnosed with clinically isolated syndrome (CIS).
Area of Science:
- Pediatric Neurology
- Neuroimmunology
- Demyelinating Diseases
Background:
- Differentiating clinically isolated syndrome (CIS) from early multiple sclerosis (MS) in children is crucial for prognosis.
- Understanding early clinical and radiological markers can aid in diagnosis and management.
Purpose of the Study:
- To compare clinical and radiological features at the initial demyelinating event in pediatric patients with CIS and MS.
- To identify predictors for the evolution from CIS to MS.
Main Methods:
- Retrospective cohort study of 38 children with CIS.
- Data collected included demographics, presentation, cerebrospinal fluid (CSF) oligoclonal bands, and brain/spinal cord MRI.
- Follow-up assessments occurred at 3, 6, 12, and 24 months.
Main Results:
- 71% of patients evolved to clinically definite MS within a mean of 11 months.
- Older age at the first demyelinating event and positive CSF oligoclonal bands were more frequent in MS patients.
- Increased T2-hyperintense lesions and specific lesion locations (periventricular, infratentorial, corpus callosum) were associated with MS development.
Conclusions:
- Older age at onset, CSF oligoclonal bands, and specific MRI lesion characteristics predict MS development in children.
- These factors are valuable for early identification and potential intervention in pediatric demyelinating diseases.
