A survey-based study of physician practices regarding biotin supplementation

Area of Science:

• Biochemistry
• Clinical Medicine
• Medical Diagnostics

Background:

• Biotin (vitamin B7) is a crucial cofactor in human metabolic pathways.
• Biotin deficiency is rare, with limited evidence supporting its use for dermatological conditions.
• A 2017 FDA safety alert highlighted biotin's interference with laboratory testing, posing diagnostic risks.

Purpose of the Study:

• To evaluate current physician practices regarding biotin recommendations.
• To assess physician awareness of biotin's interference with routine laboratory tests.

Main Methods:

• A national survey was conducted among 149 physicians.
• The survey assessed prescription habits and knowledge of biotin's laboratory test interference.

Main Results:

• 43.9% of physicians prescribe biotin, mainly for hair and nail disorders.
• 39.5% recommend biotin-containing supplements.
• While aware of interference with thyroid and troponin tests, knowledge gaps exist for other tests (e.g., b-HCG, Hepatitis, HIV, Vitamin D). 19.5% were unaware of any interference.
• Nearly half of physicians do not advise patients to stop biotin before testing.

Conclusions:

• Physicians continue prescribing biotin despite insufficient evidence for dermatological benefits and significant knowledge gaps regarding its interference with laboratory diagnostics.
• There is a critical need to enhance physician awareness of biotin's risks and benefits, particularly concerning potential diagnostic errors and patient safety.