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Joint hypermobility in children with and without functional constipation.

Seyed Mohammadreza Fatemi Khorasgani1, Neda Ramezani2, Negar Ebrahimi Varnousfaderani2

  • 1Department of Pediatrics, Islamic Azad University, Najaf Abad Branch, Isfahan, Iran.

Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences
|May 19, 2020
PubMed
Summary

Joint hypermobility (JH) is not significantly associated with functional constipation (FC) in children. Age, but not gender, showed a significant association with JH, with risk decreasing as age increases.

Keywords:
Beighton scorefunctional constipationfunctional gastrointestinal disorderjoint hypermobilityrelative frequency

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Area of Science:

  • Pediatric Gastroenterology
  • Rheumatology
  • Genetics

Background:

  • Joint hypermobility (JH), a characteristic of connective tissue disorders, is linked to autonomic dysfunction and digestive issues like irritable bowel syndrome.
  • The association between JH and functional constipation (FC) in children remains unevaluated.

Purpose of the Study:

  • To investigate the association between joint hypermobility (JH) and functional constipation (FC) in a pediatric population.
  • To determine if JH is a risk factor for FC in children.

Main Methods:

  • A case-control study involving 200 children, with 100 diagnosed with FC (case group) and 100 healthy controls.
  • Demographic data and JH were assessed using the Beighton score physical examination.
  • Children were matched for age and gender.

Main Results:

  • No significant difference in the prevalence of JH was found between children with FC and healthy controls (OR 1.13, P=0.669).
  • JH was not significantly associated with gender (P=0.445) but was significantly associated with age (P=0.041).
  • Multivariate analysis indicated that age was a significant independent predictor of JH, with a 12% decrease in JH risk for each year increase in age.

Conclusions:

  • The prevalence of JH is not significantly different in children with and without FC.
  • JH is not significantly associated with gender but is significantly associated with age in the pediatric population.
  • Age is an independent predictive factor for JH in children, with risk decreasing with advancing age.