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Updated: Dec 21, 2025
A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
Published on: May 27, 2021
G2G: A web-server for the prediction of human synthetic lethal interactions
Yom Tov Almozlino1, Iftah Peretz2, Martin Kupiec2
1School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.
Abstract:
Genetic interactions (GIs) are fundamental to our understanding of biological processes in the cell. While GIs have been systematically mapped in yeast, there is scarce information about them in humans. Recently, we have suggested a state-of-the-art hierarchical method that leverages gene ontology information for predicting GIs in yeast. Here, we adapt this method and apply it for the first time to predict GIs in human. We introduce a web service called G2G for this task that is available at http://bnet.cs.tau.ac.il/g2g/.
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