Adherence to drug therapy for hypertensive disorders of pregnancy: a cross-sectional survey

Related Experiment Video

Updated: Dec 21, 2025

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

11.0K

Haihong Chen1, Yuqing Tang1, Chenxi Liu1

  • 11School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology, No.13. Hangkong Road, Wuhan, 430030 Hubei Province China.

Archives of Public Health = Archives Belges De Sante Publique
|May 19, 2020
PubMed

Insights

Physician adherence to hypertensive disorders of pregnancy (HDPs) drug therapy guidelines in China is suboptimal, with significant gaps in magnesium sulfate use and drug dosing. Strengthening high-evidence-based recommendations is crucial for improving HDP management.

Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology
  • Public Health

Background:

  • Hypertensive disorders of pregnancy (HDPs) are a leading cause of maternal mortality globally.
  • Effective drug therapy is crucial for managing HDPs, but adherence to clinical guidelines remains a concern, particularly in China.
  • Understanding physician adherence to HDP drug therapy guidelines is essential for improving patient outcomes.

Purpose of the Study:

  • To evaluate physician adherence to the Chinese Obstetricians and Gynecologists Association (COGA) drug therapy guidelines for HDPs.
  • To explore the association between adherence to clinical decisions and the level of evidence supporting treatment recommendations.
  • To identify areas for improvement in HDP drug therapy management in China.

Main Methods:

  • A cross-sectional study was conducted with 306 women diagnosed with HDPs in Hubei, China.
  • Adherence was assessed based on six criteria: timing, route, and dosage of antihypertensive drugs, magnesium sulfate (MgSO4), and corticosteroids.
  • Binary logistic regression analysis was used to examine the relationship between adherence and recommendation evidence.

Main Results:

  • The overall average adherence rate to HDP drug therapy guidelines was 48.22%.
  • High adherence rates were observed for the timing of antihypertensive drugs (95.65%) and corticosteroids (86.75%).
  • Significantly lower adherence (<50%) was found for magnesium sulfate timing, and the routes and dosages of antihypertensive drugs, magnesium sulfate, and corticosteroids. Recommendation evidence was associated with adherence (OR=0.588, P=0.003).

Conclusions:

  • Substantial improvement is required to achieve optimal adherence to HDP drug therapy guidelines, particularly concerning magnesium sulfate administration and drug dosages.
  • Strengthening the implementation of high-evidence-based recommendations in HDP management is critical.
  • Targeted interventions focusing on specific guideline components are needed to enhance care quality for HDPs.
Abstract

Keywords:
AdherenceDrug therapyEvidenceHypertensive disordersPregnancy

More Related Videos

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.1K

Related Concept Videos

Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
472
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
275
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
364
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
613
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
1.1K
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
2.2K