Related Experiment Video

Updated: Dec 21, 2025

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Circulating biomarkers in the early detection of hypertensive heart disease: usefulness in the developing world

Dike Ojji1, Elena Libhaber2, Kim Lamont2

  • 1Cardiology Unit, Department of Medicine, University of Abuja Teaching Hospital, Abuja, Nigeria.

Cardiovascular Diagnosis and Therapy
|May 19, 2020
PubMed

Insights

Diagnosing hypertensive heart disease (HHD) is challenging. Circulating biomarkers offer a promising, accessible alternative to traditional imaging methods for assessing HHD.

Area of Science:

  • Cardiology
  • Biomarkers
  • Hypertensive Heart Disease

Background:

  • Hypertensive heart disease (HHD) diagnosis relies on methods like ECG, echocardiography, and CMR.
  • These methods have limitations including insensitivity (ECG) or high cost and limited availability (echocardiography, CMR).
  • Exploring alternative diagnostic tools like circulating biomarkers is crucial for HHD assessment.

Purpose of the Study:

  • To review the current literature on circulating biomarkers for diagnosing hypertensive heart disease (HHD).
  • To identify the most studied biomarkers in HHD diagnosis.
  • To highlight the need for further research into novel biomarkers for HHD.

Main Methods:

  • A systematic literature search was conducted on PubMed and Google Scholar databases.
  • Original articles published between 2005 and 2015 focusing on circulating biomarkers in human HHD diagnosis were included.
  • Fourteen studies met the inclusion criteria for the review.

Main Results:

  • N-terminal pro-B-type natriuretic peptide (NT-proBNP) was the most frequently studied biomarker in HHD.
  • Soluble ST2 (sST2) was the second most studied circulating biomarker in HHD.
  • The review identified a limited amount of data on circulating biomarkers for HHD diagnosis.

Conclusions:

  • Circulating biomarkers present an attractive alternative for diagnosing hypertensive heart disease (HHD) due to limitations of current imaging techniques.
  • NT-proBNP and sST2 are among the most investigated biomarkers, but data remains scarce.
  • Further investigation into circulating biomarkers is essential for advancing the diagnosis and management of HHD.

Keywords:
Rolecirculating biomarkershypertensive heart disease (HHD)

More Related Videos

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

18.2K
Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

7.9K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
364
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
437
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
562
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
689
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.5K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
613