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Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

Progress in the basic and clinical research on the Schlemm's canal.

Le-Ying Wang¹, Guan-Yu Su¹, Zhen-Yu Wei¹

¹Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China.

International Journal of Ophthalmology

|May 19, 2020

Summary

Schlemm's canal (SC) dysfunction contributes to glaucoma by increasing outflow resistance. Research reveals SC cellular changes in glaucoma and potential for therapeutic interventions targeting aqueous humor flow.

Keywords:

Schlemm's canal glaucoma pathophysiology physiology progress

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Last Updated: Dec 21, 2025

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

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Published on: June 20, 2015

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Published on: February 15, 2022

Area of Science:

Ophthalmology
Biomedical Engineering
Cell Biology

Background:

Glaucoma is a primary cause of irreversible blindness globally.
Intraocular pressure (IOP) is a critical factor in glaucoma development and progression.
Schlemm's canal (SC) regulates aqueous humor outflow and IOP.

Purpose of the Study:

To review current research on aqueous outflow resistance mechanisms.
To explore changes in Schlemm's canal in physiological and pathological states.
To discuss potential therapeutic strategies for glaucoma based on SC research.

Main Methods:

Review of basic and clinical research on Schlemm's canal.
Analysis of SC anatomy, physiology, and pathophysiology.
Investigation of advanced imaging techniques for SC assessment.

Main Results:

Glaucomatous SC cells exhibit increased stiffness and reduced porosity, leading to higher outflow resistance.
SC collapse due to acute IOP increase can be reversible.
Advanced imaging enables in vivo quantitative SC measurements.

Conclusions:

Understanding SC mechanisms is crucial for glaucoma management.
SC cellular characteristics differ significantly between normal and glaucomatous eyes.
New therapeutic paradigms for glaucoma may emerge from SC research.