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Muscle function and architecture in children with juvenile idiopathic arthritis

Pierre Bourdier1, Anthony Birat1, Emmanuelle Rochette2,3,4

  • 1Laboratoire AME2P, Université Clermont Auvergne, Clermont-Ferrand, France.

Acta Paediatrica (Oslo, Norway : 1992)
|May 19, 2020
PubMed

Insights

Children with juvenile idiopathic arthritis (JIA) show normal knee extensor strength but reduced vertical jump height. Lower intermuscular adipose tissue in JIA may indicate lower physical activity levels.

Area of Science:

  • Pediatric rheumatology
  • Musculoskeletal health
  • Arthritis research

Background:

  • Juvenile idiopathic arthritis (JIA) can impact physical function in children.
  • Understanding muscle characteristics and functional deficits is crucial for JIA management.

Purpose of the Study:

  • To compare muscle function and functional abilities in children with JIA versus healthy controls.
  • To investigate structural and qualitative muscle characteristics in JIA.

Main Methods:

  • Ultrasound and pQCT used to assess thigh muscle structure (thickness, CSA, fascicle angle) and IMAT.
  • Maximal voluntary isometric contraction (MVIC) of knee extensors and vertical jump assessed for muscle function and performance.

Main Results:

  • No significant differences in MVIC knee extensor force between JIA and control groups.
  • Children with JIA exhibited significantly lower squat jump height compared to controls.
  • Intermuscular adipose tissue relative to muscle cross-sectional area (IMAT/CSA) was lower in children with JIA.

Conclusions:

  • While knee extensor muscle architecture and force are comparable, functional performance (vertical jump) is impaired in children with JIA.
  • Reduced IMAT in JIA may be linked to decreased physical activity levels compared to healthy peers.
Abstract

Keywords:
growthinflammationintermuscular adipose tissuemusclepaediatrics

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