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Neurodevelopmental Reflex Testing in Neonatal Rat Pups
Published on: April 24, 2017
Parental Age in Relation to Offspring's Neurodevelopment
S A M Veldkamp1, M A J Zondervan-Zwijnenburg2, Elsje van Bergen1
1Department of Biological Psychology, Vrije Universiteit Amsterdam.
Insights
Children born to older parents generally exhibit better neurodevelopmental outcomes, including fewer attention problems and higher IQ and educational achievement. Parental age, particularly maternal age, positively influences child development, though socioeconomic status plays a confounding role.
Area of Science:
- Developmental Psychology
- Pediatrics
- Behavioral Genetics
Background:
- Advanced parental age is a known risk factor for severe neurodevelopmental disorders.
- The impact of parental age on general neurodevelopmental outcomes requires further investigation.
Purpose of the Study:
- To examine the association between parental age and offspring's attention problems, intelligence, and educational achievement.
- To determine if parental age influences general neurodevelopment beyond severe disorders.
Main Methods:
- Analysis of child-, father-, mother-, and teacher-rated attention problems, intelligence, and educational achievement data from four Dutch population-based cohorts.
- Bayesian research synthesis to aggregate results across cohorts, with data split for hypothesis generation and evaluation.
- Inclusion of socioeconomic status (SES) and child gender as covariates.
Main Results:
- Negative linear relations between parental age and attention problems were observed, with younger parents' offspring showing more attention issues.
- Maternal age showed a positive linear association with offspring's IQ and educational achievement.
- Paternal age had an attenuating positive relation with educational achievement and an inverted U-shape relation with IQ.
- Associations, particularly with maternal age, persisted after controlling for SES.
- Socioeconomic status partially confounded the positive relationship between parental age and offspring neurodevelopmental outcomes.
Conclusions:
- Parental age, especially maternal age, is associated with improved offspring neurodevelopmental outcomes, including attention, IQ, and educational achievement.
- The observed effects, while small, are statistically significant and indicate a benefit for children of older parents.
- Socioeconomic status is an important factor that influences and partially confounds the relationship between parental age and child neurodevelopment.
Abstract:
Objective: Advanced parenthood increases the risk of severe neurodevelopmental disorders like autism, Down syndrome and schizophrenia. Does advanced parenthood also negatively impact offspring's general neurodevelopment?Method: We analyzed child-, father-, mother- and teacher-rated attention-problems (N = 38,024), and standardized measures of intelligence (N = 10,273) and educational achievement (N = 17,522) of children from four Dutch population-based cohorts. The mean age over cohorts varied from 9.73-13.03. Most participants were of Dutch origin, ranging from 58.7%-96.7% over cohorts. We analyzed 50% of the data to generate hypotheses and the other 50% to evaluate support for these hypotheses. We aggregated the results over cohorts with Bayesian research synthesis.Results: We mostly found negative linear relations between parental age and attention-problems, meaning that offspring of younger parents tended to have more attention problems. Maternal age was positively and linearly related to offspring's IQ and educational achievement. Paternal age showed an attenuating positive relation with educational achievement and an inverted U-shape relation with IQ, with offspring of younger and older fathers at a disadvantage. Only the associations with maternal age remained after including SES. The inclusion of child gender in the model did not affect the relation between parental age and the study outcomes.Conclusions: Effects were small but significant, with better outcomes for children born to older parents. Older parents tended to be of higher SES. Indeed, the positive relation between parental age and offspring neurodevelopmental outcomes was partly confounded by SES.
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