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Treatments for COVID-19: emerging drugs against the coronavirus

Francesco Potì1, Cristina Pozzoli2, Maristella Adami3

  • 1Department of Medicine and Surgery - Unit of Neurosciences, University of Parma, Parma, Italy. francesco.poti@unipr.it.

Acta Bio-Medica : Atenei Parmensis
|May 19, 2020
PubMed

Insights

This review highlights emerging pharmacological treatments for Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2. It examines promising drug candidates and ongoing clinical trials for effective COVID-19 therapies.

Area of Science:

  • Virology
  • Pharmacology
  • Infectious Diseases

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, poses a significant global public health threat.
  • Currently, no definitive therapies exist for this novel viral infection.
  • A rapid increase in understanding of SARS-CoV-2 virology, host responses, and disease progression is driving therapeutic development.

Purpose of the Study:

  • To review the most recent and promising pharmacological treatments for COVID-19 currently under investigation.
  • To discuss the potential application of these treatments based on efficacy in similar viral infections or anti-inflammatory properties.
  • To highlight ongoing clinical trials evaluating these therapeutic strategies.

Main Methods:

  • Literature review of emerging pharmacological treatments for COVID-19.
  • Analysis of drug candidates based on existing data for viral infections and inflammatory conditions.
  • Emphasis on ongoing clinical trials and their objectives.

Main Results:

  • Identification of several promising drug targets and therapeutic agents for COVID-19.
  • Evaluation of treatment potential based on cross-applicability from other viral diseases and inflammatory syndromes.
  • Overview of the current landscape of clinical trials investigating novel COVID-19 therapies.

Conclusions:

  • The development of effective COVID-19 therapies is progressing rapidly due to a deepening understanding of the virus and disease.
  • Investigational drugs show promise, with ongoing trials crucial for validating their efficacy and safety.
  • A multi-faceted approach combining public health measures with targeted pharmacological interventions is essential for combating the COVID-19 pandemic.

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