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Updated: Dec 21, 2025
Synthesis of an Intein-mediated Artificial Protein Hydrogel
Published on: January 27, 2014
Control of microenvironment around enzymes by hydrogels
Yuichiro Kobayashi1, Kenji Kohara1, Yusuke Kiuchi1
1Department of Macromolecular Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan. hiroyasu@chem.sci.osaka-u.ac.jp.
Abstract:
We prepared enzyme-immobilized hydrogels and investigated the effects of the cross-linking density and polymer properties on their oxidation reaction rate. The oxidation rate of enzyme-immobilized hydrogels increased as the cross-linking density in the hydrogels increased. In addition, we controlled the oxidation rate using hydrogels exhibiting an appropriate interaction with a decoy molecule in the hydrogel.
