Related Experiment Video

Updated: Dec 21, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

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Simultaneous administration of imipenem/cilastatin/relebactam with selected intravenous antimicrobials, a stewardship

Islam M Ghazi1, Wasim S El Nekidy2, Regan Asay1

  • 1Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA, United States of America.

Plos One
|May 19, 2020
PubMed

Insights

Imipenem/cilastatin/relebactam (Recarbrio®) is compatible with most antimicrobials for Y-site administration, simplifying treatment for severe infections. This compatibility study supports optimized drug administration, reducing infusion times and healthcare costs.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • Imipenem/cilastatin/relebactam (Recarbrio®) is FDA-approved for complicated infections.
  • It targets resistant bacteria like imipenem-non-susceptible Pseudomonas and KPC-producing Enterobacteriaceae.
  • Optimizing antimicrobial pharmacokinetics/pharmacodynamics (PK/PD) in critically ill patients is crucial but challenging due to separate administration needs.

Purpose of the Study:

  • To assess the Y-site administration compatibility of imipenem/cilastatin/relebactam with various antimicrobial agents.
  • To provide data supporting the co-administration of imipenem/cilastatin/relebactam with other antimicrobials.

Main Methods:

  • Physical characteristics, pH, and turbidity were measured for 2-drug admixtures.
  • Imipenem/cilastatin/relebactam was combined with a wide range of antimicrobial agents.
  • Compatibility was assessed after admixture at a specific time point.

Main Results:

  • Imipenem/cilastatin/relebactam demonstrated compatibility with a broad spectrum of antimicrobial agents.
  • Exceptions included amphotericin B deoxycholate and posaconazole.
  • No significant physical incompatibilities were observed with compatible agents.

Conclusions:

  • Y-site administration of imipenem/cilastatin/relebactam with most antimicrobials is feasible.
  • This compatibility facilitates hospital protocol integration and therapy optimization.
  • Co-administration can reduce total infusion time, optimize PK/PD, and contain costs.

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