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Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids

Pankajini Mallick1, Gina Song1, Alina Y Efremenko1

  • 1ScitoVation, LLC, Durham, North Carolina 27713.

Toxicological Sciences : an Official Journal of the Society of Toxicology
|May 19, 2020
PubMed
Summary

Children show lower or equal internal exposure to pyrethroid insecticides than adults. Physiologically based pharmacokinetic (PBPK) modeling confirms no additional safety factor is needed for age-related differences in risk assessment.

Keywords:
IVIVEPBPK modelingpyrethroidsrisk assessment

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