HLA-DR-expressing NK cells: Effective killers suspected for antigen presentation
Sofya A Erokhina1, Maria A Streltsova1, Leonid M Kanevskiy1
1Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
Journal of Leukocyte Biology
|May 19, 2020
Summary
Human leukocyte antigen (HLA)-DR-expressing Natural Killer (NK) cells possess traits of both NK and dendritic cells. This review details their phenotype, development, and function in health and disease.
Area of Science:
- Immunology
- Cell Biology
Background:
- Natural Killer (NK) cells expressing Human Leukocyte Antigen (HLA)-DR bridge NK cells and dendritic cells.
- These cells are found in human and mouse blood and tissues, both in health and disease.
Purpose of the Study:
- To provide a comprehensive analysis of HLA-DR+ NK cells.
- To describe their phenotypic, developmental, and functional characteristics in healthy and diseased states.
Main Methods:
- Literature review of existing data on HLA-DR+ NK cells.
Main Results:
- HLA-DR+ NK cells exhibit functional activity, including cytokine production, degranulation, and proliferation.
- These cells can present antigens to T cells, similar to professional antigen-presenting cells.
- They play a role in regulating innate and adaptive immune responses.
Conclusions:
- HLA-DR+ NK cells are significant components of the innate immune system.
- Their dual characteristics suggest a crucial role in immune regulation and response.
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