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Related Concept Videos

The Extracellular Matrix01:42

The Extracellular Matrix

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The Extracellular Matrix01:29

The Extracellular Matrix

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In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
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Extracellular Matrix01:26

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Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

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Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
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Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

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Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
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Extracellular matrix: The proteins that function throughout the body.

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PubMed
Summary
This summary is machine-generated.

This collection explores the extracellular matrix (ECM), covering its structure, genetics, and role in development, cancer, and healing. It features diverse research on ECM

Keywords:
CD147EMMPRINSPARCWARPangiogenesiscollagencorneaextracellular matrixextracellular vesiclesfibrillingeneticsinflammationmetalloproteaseneuromuscular junctionpalatevasculogenesiswound healing

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Area of Science:

  • Extracellular Matrix Biology
  • Cellular Biology
  • Biomedical Research

Background:

  • This special issue consolidates research on the extracellular matrix (ECM), a critical component of tissues.
  • Planning began over four years ago, with manuscript submissions and reviews occurring in 2018-2019.

Discussion:

  • The collection is organized into seven key themes: ECM structure, genetics, development, cancer, vascular biology, inflammation, wound healing, collagen, ocular tissues, and extracellular vesicles.
  • It includes 6 reviews, 13 original research papers, and 4 remembrances, offering a comprehensive overview.

Key Insights:

  • Highlights advancements in understanding ECM's multifaceted roles in physiological and pathological processes.
  • Showcases the latest findings on ECM's involvement in cancer, vascular development, and tissue repair.

Outlook:

  • This volume serves as a valuable resource for researchers investigating the extracellular matrix.
  • Future research directions may focus on therapeutic interventions targeting ECM in various diseases.