Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

4.5K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
4.5K
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

6.1K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
6.1K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

502
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
502
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

1.2K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.2K
Lipid Catabolism01:25

Lipid Catabolism

714
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
714
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

779
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
779

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conspecific alarm cues induce chemical but not morphological defenses in Pseudo-nitzschia.

Journal of phycology·2026
Same author

An entropy-regulating molecular lock stabilizes formamidinium lead halide perovskite.

Science (New York, N.Y.)·2026
Same author

Spleen-brain axis regulates myelin integrity via TGF-β1 signaling in cuprizone-induced demyelination and remyelination model.

European journal of pharmacology·2026
Same author

Antibiotic-induced Microbiome Depletion Selectively Reduces Baseline Hypothalamic Oxytocin Signaling without Affecting MDMA-induced Oxytocin Response in Rats.

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology·2026
Same author

Influencing Factors of Perceived Stress in Different Periods of Public Health Emergencies: A Cross-Sectional Study Among Nursing Interns: Empirical Research Quantitative.

Nursing open·2026
Same author

Dietary sulforaphane glucosinolate alleviates stress-induced depression and demyelination through gut-brain axis modulation.

The Journal of nutritional biochemistry·2026
Same journal

PFKFB2-Induced Glycolysis and Ferroptosis in Diabetic Nephropathy by HIF-1α.

Critical reviews in eukaryotic gene expression·2026
Same journal

LncRNA MANCR Acts as a ceRNA to Sponge MicroRNA-20a-5p and Upregulate GCNT4 to Suppress Angiogenesis in Colorectal Cancer.

Critical reviews in eukaryotic gene expression·2026
Same journal

Mechanistic Study of the Pink1/Parkin Signaling Pathway in Mitochondrial Dysfunction and Podocyte Injury.

Critical reviews in eukaryotic gene expression·2026
Same journal

Recent Advances in CRISPR-Cas Systems for Dengue Virus Detection.

Critical reviews in eukaryotic gene expression·2026
Same journal

A Lack of Association between Vitamin D Receptor Gene Polymorphisms with Colorectal Cancer: A Comprehensive Meta-Analysis and Power Assessment.

Critical reviews in eukaryotic gene expression·2026
Same journal

Use of Rituximab in Pediatric Nephrology: A Bibliometric and Visualization Analysis from 2003 to 2024.

Critical reviews in eukaryotic gene expression·2025
See all related articles

Related Experiment Video

Updated: Dec 21, 2025

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
07:11

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

3.1K

Correlation Network Analysis Provides Important Modules and Pathways for Human Hyperlipidemia.

Shipeng Zhu1, Huan Chen2, Xintai Zhu3

  • 1Second School of Clinical Medicine of Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Critical Reviews in Eukaryotic Gene Expression
|May 19, 2020
PubMed
Summary
This summary is machine-generated.

Protein ubiquitination and cell-cell adhesion pathways are key in hyperlipidemia. This study identified crucial co-expression modules, enhancing understanding of hyperlipidemia pathogenesis and potential diagnostic markers.

More Related Videos

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.6K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.9K

Related Experiment Videos

Last Updated: Dec 21, 2025

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
07:11

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

3.1K
Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.6K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.9K

Area of Science:

  • Genomics and Bioinformatics
  • Molecular Biology
  • Systems Biology

Background:

  • Hyperlipidemia poses significant global health risks.
  • Systemic co-expression and functional pathway analysis for hyperlipidemia remains underexplored.
  • Understanding molecular mechanisms is crucial for diagnosis and treatment.

Purpose of the Study:

  • To identify co-expression modules associated with hyperlipidemia.
  • To explore hyperlipidemia-related functional pathways.
  • To uncover potential diagnostic and prognostic biomarkers for hyperlipidemia.

Main Methods:

  • Utilized weighted gene co-expression network analysis (WGCNA) on human hyperlipidemia gene expression data (GSE17170).
  • Constructed co-expression modules using the top 3,000 highly expressed genes.
  • Performed Gene Ontology (GO) and KEGG pathway enrichment analysis via DAVID database.

Main Results:

  • Identified 13 co-expression modules from 3,000 genes across 70 samples.
  • Modules 3 and 4 showed significant enrichment in protein ubiquitination pathways (e.g., GO:0016567, hsa04120).
  • Cell-cell adhesion (GO:0098609) was enriched in multiple modules, indicating its importance in hyperlipidemia.

Conclusions:

  • Protein ubiquitination pathways are strongly implicated in the pathogenesis of human hyperlipidemia.
  • Co-expression modules related to ubiquitination and cell-cell adhesion offer insights into disease mechanisms.
  • Findings contribute to a deeper understanding of hyperlipidemia and may aid in developing diagnostic and outcome evaluation tools.