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Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

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Updated: Dec 21, 2025

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Published on: December 15, 2023

HDVdb: A Comprehensive Hepatitis D Virus Database.

Zainab Usman¹, Stoyan Velkov², Ulrike Protzer²

¹Department of Bioinformatics, Wissenschaftszentrum Weihenstephan, Technische Universität München, 85354 Freising, Germany.

|May 20, 2020

Summary

This summary is machine-generated.

Hepatitis D virus (HDV) causes severe hepatitis. A new database, HDVdb, aids research into HDV genetic variability, epidemiology, and the development of treatments and vaccines.

Keywords:

Webserver database genotyping hepatitis delta virus

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Area of Science:

Virology
Hepatology
Bioinformatics

Background:

Hepatitis D virus (HDV) infection leads to severe viral hepatitis, potentially causing liver cirrhosis and hepatocellular carcinoma (HCC).
An estimated 15-20 million individuals globally are chronically infected with HDV.
Currently, no effective treatments exist for acute or chronic HDV infections.

Purpose of the Study:

To introduce HDVdb, a specialized database for Hepatitis D virus genomic sequences.
To facilitate research on HDV genetic variability, genotype-epidemiology correlations, and pathogenesis.
To support the understanding of drug resistance and the development of HDV vaccines.

Main Methods:

Compilation of partial and complete HDV genomic sequences from GenBank and a patient cohort.
Development of a web-accessible database (HDVdb) with a user-friendly interface.
Integration of generic and specialized sequence analysis tools, including annotation, genotyping, primer prediction, and phylogenetic analysis.

Main Results:

HDVdb provides a centralized resource for diverse HDV genomic sequences.
The database enables comprehensive investigation of HDV genetic diversity and its clinical implications.
Integrated tools facilitate in-depth analysis of HDV sequences for research purposes.

Conclusions:

HDVdb is a valuable resource for the scientific community studying Hepatitis D virus.
The database will advance understanding of HDV epidemiology, pathogenesis, and drug resistance.
HDVdb is expected to contribute significantly to the development of effective HDV therapies and vaccines.