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Updated: Dec 21, 2025
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
History of Cyclodextrin Nanosponges
Ilona Krabicová1, Silvia Lucia Appleton2, Maria Tannous2
1Department of Nanochemistry, Advanced Technologies and Innovation, Technical Institute for Nanomaterials, University of Liberec, Studentská 1402/2, 461 17 Liberec, Czech Republic.
Cyclodextrin nanosponges (CD NSs), derived from polysaccharides, offer unique nanoporous structures for advanced drug delivery. This review traces their 50-year evolution from simple networks to multifunctional polymers, highlighting their broad applications.
Area of Science:
- Nanotechnology and Nanomedicine
- Polymer Science
- Materials Science
Background:
- Polysaccharides are favored in nanomedicine for their safety, biodegradability, and low cost.
- Cyclodextrin-based nanosponges (CD NSs) possess unique nanoporous, sponge-like structures derived from crosslinked cyclodextrin units.
- CD NSs overcome limitations of native cyclodextrins, enhancing encapsulation of diverse molecules.
Purpose of the Study:
- To provide a comprehensive overview of cyclodextrin-based nanosponges (CD NSs) research.
- To trace the historical development of nanosponges over the past 50 years.
- To explore the evolution of CD NSs from simple networks to advanced multifunctional polymers.
Main Methods:
- Literature review focusing on the historical development of nanosponges.
- Analysis of the structural properties and functionalization of CD NSs.
- Examination of the applications of CD NSs in various scientific fields.
Main Results:
- CD NSs exhibit tunable properties based on cyclodextrin type, crosslinker, and crosslinking degree.
- These nanostructures have enabled significant advancements in agroscience, pharmaceuticals, and biotechnology.
- Research continues to explore novel applications and functionalities of CD NSs.
Conclusions:
- CD NSs represent a significant advancement in nanotechnology and nanomedicine.
- Their unique structure and versatile properties position them for continued innovation.
- The historical perspective provides insights into the future potential of CD NSs in diverse applications.
