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Effect of feeding mode on infant growth and cognitive function: study protocol of the Chilean infant Nutrition

Rosario Toro-Campos1, Cecilia Algarín2, Patricio Peirano2

  • 1Institute of Nutrition and Food Technology (INTA), University of Chile, Av El Libano 5524, Macul, Santiago, Chile. rosario.toro@inta.uchile.cl.

BMC Pediatrics
|May 20, 2020
PubMed

Insights

Adding bovine milk fat globule membranes (bMFGM) to infant formula may support healthy physical growth and brain development in early infancy. This study compared bMFGM-enriched formula to standard formula and human milk.

Area of Science:

  • Pediatric Nutrition
  • Infant Development
  • Dairy Science

Background:

  • Developing infant formula closer to human milk is a key goal in pediatric nutrition.
  • Milk fat globule membranes (MFGM) contain functional components found in human milk.
  • Bovine MFGM (bMFGM) addition to infant formula may offer benefits, narrowing the gap with human breast milk.

Purpose of the Study:

  • To assess the impact of bMFGM-enriched infant formula on physical growth and brain development.
  • To compare outcomes in infants fed bMFGM-enriched formula versus standard formula.
  • To compare outcomes in formula-fed infants against a reference group fed mother's own milk.

Main Methods:

  • A single-center, double-blind, parallel randomized controlled trial.
  • Infants were fed either standard formula (SF) or bMFGM-enriched formula (EF) until 12 months of age.
  • Primary outcomes included physical growth and cognitive development (Auditory Event-Related Potential) at 730 days.

Main Results:

  • Results are pending, but the study aims to provide data on the effects of bMFGM in infant formula.
  • The study will analyze physical growth (weight, length, head circumference) and cognitive development.
  • Data will be analyzed for all participants randomized to each feeding group.

Conclusions:

  • The study's findings will contribute to understanding the role of bMFGM in infant nutrition.
  • Results are expected to inform the development of infant formulas that better support healthy growth and neurodevelopment.
  • This research may help optimize infant formula composition for improved infant outcomes.
Abstract

Keywords:
Breast feedingChileClinical trialsInfant formulaMilk fat globule membrane, MFGM, growth and development

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