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MRI perfusion analysis using freeware, standard imaging software.

Antje Hartmann1, Volkher B Scholz2, Ines E Lautenschläger3

  • 1Veterinary Clinic Hofheim, Katharina-Kemmler-Str. 7, 65719, Hofheim, Germany. drantjehartmann@gmail.com.

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This summary is machine-generated.

A new R package offers free, open-source perfusion-weighted imaging analysis for veterinary medicine. This tool calculates key perfusion parameters, aiding research and diagnosis in animal brain imaging.

Keywords:
BrainCBFCanineHoros®Machine learningMagnetic resonance imagingOsiriX®PWIR package

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Area of Science:

  • Veterinary neurology
  • Medical imaging analysis
  • Computational biology

Background:

  • Perfusion-weighted imaging (PWI) is underutilized in veterinary medicine due to high software costs and algorithm limitations.
  • Existing PWI analysis tools are often expensive, difficult to adapt for veterinary use, and hinder result comparability.
  • There is a need for accessible, adaptable PWI analysis solutions in veterinary research.

Purpose of the Study:

  • To develop a free, open-source R package for calculating quantitative perfusion parameters.
  • To enable easier use, comparison, and adaptation of PWI analysis in veterinary medicine.
  • To demonstrate the software's utility with previously acquired PWI data.

Main Methods:

  • An R package was developed to compute mean transit time, cerebral blood flow, and cerebral blood volume.
  • The package processes data from freely available imaging software (OsiriX Light®).
  • Regions of interest (ROIs) were defined, enhancement curves generated, and signal intensity data exported for analysis.

Main Results:

  • The R package was used to re-analyze existing perfusion-weighted images from healthy dogs and dogs with idiopathic epilepsy.
  • Analysis revealed a significant increase in mean transit time and a decrease in cerebral blood flow in diseased dogs.
  • The findings align with previous clinical results, validating the software's accuracy.

Conclusions:

  • An R package for computing key perfusion parameters from standard imaging software measurements is now available.
  • The open-source nature and adaptability of the package aim to facilitate PWI analysis in veterinary medicine.
  • This contribution promotes standardized, comparable, and accessible PWI data analysis for veterinary researchers.