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Desirability and acceptability of a treatment-sequencing model in relapsing-remitting multiple sclerosis: A health

Marjanne A Piena¹, Olaf Schoeman², Gerard T Harty³

¹Pharmerit International, Rotterdam, The Netherlands.

International Journal of Technology Assessment in Health Care

|May 20, 2020

Abstract

Objective:

Gather health technology assessment (HTA) experts' insights on the desirability and acceptability of treatment-sequencing models applied to relapsing-remitting multiple sclerosis (RRMS).

Data Source/Study Setting:

Primary data.

Study Design:

In-depth double-blind semi-structured telephone interviews.

Data Collection/Extraction Methods:

General themes were extracted from qualitative interviews.

Principal Findings:

Although experts confirmed the importance of evaluating the clinical and cost-effectiveness of treatments as part of a sequence, the current HTA decision making framework is not conducive to this. Developing an RRMS treatment-sequencing model that meets HTA requirements is difficult, in particular due to scarcity of effectiveness data in later treatment lines.

Conclusions:

At present, a treatment-sequencing model for RRMS may be desirable yet not requested by HTA bodies for their decision making. However, there could be other areas where a treatment-sequencing model for RRMS is of use.

Keywords:

Health technology assessment Relapsing-remitting multiple sclerosis Treatment switching Treatment-sequencing model

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