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Cellular immunity in lobomycosis (keloidal blastomycosis)
1Faculdade de Ciencias da Saude, Manaus, Amazonas, Brazil.
Allergologia Et Immunopathologia
|November 1, 1988
Summary
Patients with lobomycosis, a fungal infection, exhibit partial cellular immunodeficiency. Their immune systems struggle with certain antigens, indicating a compromised cellular response.
Area of Science:
- Immunology
- Infectious Diseases
- Dermatology
Background:
- Lobomycosis is a chronic fungal infection endemic to the Amazon basin.
- The cellular immune response in lobomycosis patients requires further elucidation.
- Understanding immune status is crucial for managing chronic infections.
Purpose of the Study:
- To assess the cellular immune response in patients with lobomycosis.
- To evaluate delayed hypersensitivity reactions and skin allograft rejection.
- To investigate immune cell function in individuals affected by this fungal disease.
Main Methods:
- Assessed delayed skin reactions to various bacterial and fungal antigens.
- Studied skin allograft rejection times.
- Evaluated sensitization to dinitrochlorobenzene (DNCB).
Main Results:
- Majority of patients showed negative delayed skin reactions to common bacterial/fungal antigens.
- High reactivity observed towards mycobacterial antigens.
- 92% of patients were non-reactive to DNCB, and skin allografts rejected in an average of 17 days.
Conclusions:
- Lobomycosis patients demonstrate partial cellular immunodeficiency.
- Impaired cellular immunity may contribute to the pathogenesis or chronicity of lobomycosis.
- Further research into immune modulation strategies for lobomycosis is warranted.