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Posterior scleral deformation and autonomic dysfunction in normal tension glaucoma
Da Young Shin1, Soo Ji Jeon1, Hae Young Lopilly Park1
1Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.
Scientific Reports
|May 20, 2020
Summary
Autonomic dysfunction may be linked to myopia progression in glaucoma patients. This study found higher posterior scleral deformation in glaucoma patients with a high possibility of autonomic dysfunction.
Area of Science:
- Ophthalmology
- Autonomic Neuroscience
Background:
- Myopia is a known risk factor for glaucoma.
- Autonomic dysfunction is increasingly implicated in glaucoma progression due to vascular dysregulation.
- Previous research lacked clinical studies on the association between the autonomic nervous system and ocular growth.
Purpose of the Study:
- To investigate the relationship between autonomic dysfunction and myopic deformation in open-angle glaucoma patients.
- To evaluate if heart rate variability (HRV) parameters correlate with specific myopic features.
Main Methods:
- 208 open-angle glaucoma patients were enrolled.
- Heart rate variability (HRV) was measured using the standard deviation of normal-to-normal intervals (SDNN) as an index of autonomic influence.
- Patients were categorized into low (LoAD) and high (HiAD) possibility of autonomic dysfunction groups based on SDNN.
- Myopic features were assessed using the posterior scleral profile, including disc tilt ratio, disc torsion, fovea-BMO center (FoBMO) angle, and peripapillary area (PPA) to disc ratio.
Main Results:
- The HiAD group exhibited greater posterior scleral deformation compared to the LoAD group.
- Specific indicators of deformation, such as axial length, disc tilt, and torsion degree, were higher in the HiAD group.
Conclusions:
- The study suggests a potential association between myopic deformation and autonomic dysfunction in glaucoma patients.
- Autonomic dysfunction may play a role in the development or progression of myopic changes in the glaucomatous eye.
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