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Near-Infrared Multipurpose Lanthanide-Imaging Nanoprobes
1Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.
Chemistry, an Asian Journal
|May 20, 2020
Summary
Lanthanide-doped nanoparticles (LDNPs) offer advanced optical imaging for deeper, clearer diagnostics. This review highlights their use in near-infrared (NIR) and NIR-II imaging for biomedical research and clinical applications.
Area of Science:
- Biomedical Optics
- Materials Science
- Nanotechnology
Background:
- Optical imaging is crucial in biomedical research and clinical settings due to its high sensitivity and resolution.
- Lanthanide-doped nanoparticles (LDNPs) are versatile luminescent materials with excellent photostability and tunable spectral properties.
- LDNPs enable advanced imaging techniques in the near-infrared (NIR) and second near-infrared window (NIR-II) for deeper tissue penetration.
Purpose of the Study:
- To review recent advancements in LDNP-based multipurpose imaging probes.
- To summarize the principles and design strategies for lanthanide-imaging nanoprobes (LINPs).
- To discuss the biophotonic applications and future clinical translation of LINPs.
Main Methods:
- Review of recent literature on LDNP applications in optical imaging.
- Analysis of upconversion, downshifting, lifetime, photoacoustic, and multimodal imaging techniques.
- Focus on nanoprobes operating in the NIR (650-1000 nm) and NIR-II (1000-1700 nm) regions.
Main Results:
- LDNPs facilitate deeper and clearer diagnostics in complex biological environments.
- Various functional, activatable, multiplexing, and multimodal LINPs have been developed.
- Representative biophotonic applications demonstrate the potential of these nanoprobes.
Conclusions:
- LDNPs are highly promising for advanced optical imaging in biomedical research.
- Further development is needed to overcome challenges for clinical translation of LINPs.
- Future research should focus on enhancing probe design and validating clinical utility.
