Challenges in pharmacotherapy for older adults: a framework for pharmacogenomics implementation

Area of Science:

• Geriatric Medicine
• Pharmacogenomics
• Clinical Pharmacology

Background:

• Older adults face significant risks from inappropriate prescribing, polypharmacy, and adverse drug events due to multimorbidity.
• Geriatric syndromes exacerbate medication-related problems in the elderly population.

Purpose of the Study:

• To explore the potential of pharmacogenomics in optimizing patient care for older adults.
• To identify strategies for implementing pharmacogenomics in geriatrics.
• To address barriers hindering the clinical adoption of pharmacogenomics.

Main Methods:

• A comprehensive review of pharmacogenomic applications in geriatric medicine.
• Analysis of educational and interprofessional strategies for implementation.
• Identification of economic, workflow, and informatics barriers.

Main Results:

• Pharmacogenomics offers a pathway to personalized medicine, minimizing adverse drug events and simplifying complex regimens for older adults.
• A multilayered, bottom-up approach is essential for integrating pharmacogenomics, including curriculum and patient/provider education.
• Key barriers include economic factors, workflow integration, and informatics support.

Conclusions:

• Successful pharmacogenomics implementation in geriatrics necessitates overcoming practical barriers through innovative practices and interdisciplinary collaboration.
• Ongoing interprofessional continuing education is crucial for healthcare providers.
• A cultural shift towards innovative patient care is paramount for realizing the benefits of pharmacogenomics in older adults.