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Intraventricular nafcillin-induced seizures in a neonate
B S Brozanski1, M S Scher, A L Albright
1Department of Pediatrics, Magee-Womens Hospital, Pittsburgh, PA 15213.
Pediatric Neurology
|May 1, 1988
Insights
Intraventricular nafcillin in a premature infant caused seizures. This highlights the critical need for electroencephalographic monitoring during intraventricular antibiotic therapy for shunt infections.
Area of Science:
- Neonatal neurology
- Pediatric infectious diseases
- Neurocritical care
Background:
- Cerebrospinal fluid (CSF) shunt infections are serious complications in infants.
- Treatment typically involves intravenous and intraventricular antibiotics.
Observation:
- A premature infant receiving intraventricular nafcillin developed seizures.
- This adverse event occurred despite standard antibiotic treatment protocols.
Findings:
- Intraventricular nafcillin administration was temporally associated with seizure activity.
- The specific mechanism linking intraventricular nafcillin to seizures in neonates requires further investigation.
Implications:
- Electroencephalographic (EEG) monitoring is crucial for neonates receiving intraventricular antibiotics.
- This case underscores potential neurotoxicity of antibiotics administered directly into the cerebrospinal fluid.
- Clinical practice guidelines may need updates regarding neurophysiologic monitoring during intraventricular antibiotic therapy.
Abstract:
Treatment of cerebrospinal fluid shunt infections commonly involves a combination of intravenous and intraventricular antibiotics. We report a premature infant who developed seizures associated with intraventricular administration of nafcillin and discuss the need for electroencephalographic monitoring of patients receiving intraventricular antibiotics.