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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
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Diabetes: Symptoms, Diagnosis, and Complications01:15

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Overview of Carbohydrate Metabolism01:19

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Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
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Psychoneuroimmunology: Diabetes and Cancer01:19

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
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Related Experiment Video

Updated: Dec 21, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

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Diabetes and COVID-19.

Béatrice Bouhanick1, Jean-Luc Cracowski2, Jean-Luc Faillie3

  • 1Service d'hypertension artérielle et thérapeutique PCVM, UMR 1027, université de Toulouse 3, CHU de Rangueil, 31059 Toulouse, France.

Therapie
|May 20, 2020
PubMed
Summary

Diabetes is not proven to increase COVID-19 infection risk. While glucose-lowering drugs show no clear harm or benefit, insulin is preferred for severe cases, and vigilance is needed as infections impact glucose control.

Keywords:
COVID-19DPP-4 inhibitorsDiabetesDiabetes drugsEpidemiologyRecommendations

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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
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Area of Science:

  • Endocrinology
  • Virology
  • Pharmacology

Background:

  • Diabetes mellitus is a known risk factor for severe COVID-19 outcomes.
  • The role of diabetes per se in increasing SARS-CoV-2 susceptibility remains unclear.
  • Limited research exists on the impact of antidiabetic drugs on COVID-19 severity.

Purpose of the Study:

  • To investigate whether diabetes itself is a risk factor for contracting COVID-19.
  • To review the current evidence on the influence of glucose-lowering agents on COVID-19 patient outcomes.
  • To discuss the role of Dipeptidylpeptidase-4 (DPP-4) and its inhibitors in the context of COVID-19.

Main Methods:

  • Literature review of existing studies on diabetes, antidiabetic drugs, and COVID-19.
  • Analysis of data concerning Dipeptidylpeptidase-4 (DPP-4) and its involvement in viral infections.
  • Examination of French and international clinical recommendations.

Main Results:

  • No conclusive evidence suggests diabetes increases the probability of SARS-CoV-2 infection.
  • Current data indicate that glucose-lowering drugs, including DPP-4 inhibitors, do not demonstrate significant harm or benefit in COVID-19 patients.
  • Insulin is recommended as the primary agent for critically ill hospitalized patients; other agents may need suspension in unstable cases.

Conclusions:

  • Diabetes per se is not established as a risk factor for acquiring COVID-19.
  • Antidiabetic medications generally show a neutral effect on COVID-19 course, but clinical judgment is essential.
  • Infections can disrupt glucose homeostasis, necessitating heightened monitoring and management, with insulin as the preferred choice for severe illness.