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Triterpenoids From Alisma Species: Phytochemistry, Structure Modification, and Bioactivities
Pengli Wang1, Tongxin Song1, Rui Shi1
1Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Triterpenoids from Alisma species, used in traditional medicine, exhibit diverse bioactivities like anticancer and anti-inflammatory effects. This review summarizes their properties and explores structure modifications to improve anticancer activity.
Area of Science:
- Phytochemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Alisma species, including Alisma orientale (Ze Xie/Takusha), are utilized in traditional medicine.
- Their tubers are rich in triterpenoids, a class of secondary metabolites.
- Triterpenoids possess a wide range of reported bioactivities.
Purpose of the Study:
- To review the phytochemical and pharmacological profiles of triterpenoids from Alisma species.
- To explore structure-activity relationships for enhancing triterpenoid cytotoxicity.
Main Methods:
- Literature review of phytochemical and pharmacological studies on Alisma triterpenoids.
- Analysis of reported bioactivities, including anticancer, lipid-regulating, anti-inflammatory, antibacterial, antiviral, and diuretic effects.
- Examination of structure modification strategies.
Main Results:
- Triterpenoids are the primary bioactive compounds in Alisma species.
- These compounds demonstrate significant anticancer, anti-inflammatory, and other therapeutic properties.
- Structure modification presents a viable approach to enhance cytotoxicity.
Conclusions:
- Alisma triterpenoids are promising therapeutic agents with diverse pharmacological activities.
- Further research into structure modification can optimize their anticancer potential.
- This review provides a foundation for developing novel Alisma-derived drugs.
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