Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

1.1K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.1K
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

355
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
355
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

1.7K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.7K
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

1.4K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
1.4K
Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

318
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
318
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

655
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
655

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Predictive value of NLMR, PLR, and ferritin in relation to SOFA, APACHE II, and SAPS II in sepsis patients.

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)·2026
Same journal

Echocardiographic factors associated with prolonged duration of inotrope therapy and ICU length of stay in a retrospective study of cardiac surgery patients.

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)·2026
Same journal

Predictive ability of malnutrition screening tools in enterally fed, mechanically ventilated patients with phase angle inference: A prospective observational study.

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)·2026
Same journal

Effect of premorbid beta-blockers on cardiac function and clinical outcomes in septic patients: a retrospective study.

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)·2026
Same journal

Influence of different short peripheral cannula materials on the incidence of phlebitis in intensive care units: A post-hoc analysis of the AMOR-VENUS study.

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)·2026
Same journal

Positive fluid balance is associated with earlier acute kidney injury in COVID-19 patients.

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)·2026
See all related articles

Related Experiment Video

Updated: Dec 21, 2025

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.8K

Catastrophic Caustic Ingestion: A Case Report.

Kerri L Bouchard1

  • 1University of Maryland Medical Center, Baltimore, USA.

Journal of Critical Care Medicine (Universitatea De Medicina Si Farmacie Din Targu-Mures)
|May 20, 2020
PubMed
Summary
This summary is machine-generated.

Intentional caustic ingestion, such as drain cleaner, can cause severe gastrointestinal injury. Despite medical care, complications like fistulas can be fatal, highlighting the risks of these ingestions.

Keywords:
caustic ingestioncaustic injuriessuicidetoxic ingestion

More Related Videos

A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis
07:33

A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis

Published on: March 15, 2016

9.3K
A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
07:40

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

9.3K

Related Experiment Videos

Last Updated: Dec 21, 2025

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube

Published on: April 28, 2020

11.8K
A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis
07:33

A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis

Published on: March 15, 2016

9.3K
A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
07:40

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

9.3K

Area of Science:

  • Gastroenterology
  • Toxicology
  • Emergency Medicine

Background:

  • Oral ingestion of caustic substances in adults is often intentional, leading to varied and potentially fatal outcomes.
  • Injuries span from superficial burns to extensive gastrointestinal necrosis.
  • Management requires identifying the substance and providing prompt treatment for immediate and long-term complications.

Purpose of the Study:

  • To present a case of severe injury following intentional caustic ingestion.
  • To illustrate the potential for life-threatening complications despite medical intervention.

Main Methods:

  • A case report of a 57-year-old male patient who intentionally ingested drain cleaner.
  • Emergency esophagogastroduodenoscopy (EGD) was performed.
  • The patient received intensive medical and supportive care during a prolonged hospital course.

Main Results:

  • Emergent EGD revealed extensive esophageal and gastric damage.
  • The patient survived the initial injury but developed fatal tracheoesophageal and bronchoesophageal fistulas.
  • The fistulas were deemed surgically unreparable, leading to the patient's death.

Conclusions:

  • Sequelae of caustic ingestion range from minor to severe, occurring immediately or delayed.
  • Even with prompt management and supportive care, mortality can result from initial injury or subsequent complications.
  • This case underscores the severe, potentially fatal consequences of intentional caustic ingestion.