Related Experiment Video

Updated: Dec 21, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Published on: August 30, 2018

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Improving the Compliance of Intraoperative Antibiotic Redosing: A Quality Improvement Initiative

Michelle M LeRiger1,2, Amber R Phipps3, Bridget M Norton4,5

  • 1Department of Anesthesiology, University of Nebraska Medical Center, Omaha, Neb.

Pediatric Quality & Safety
|May 20, 2020
PubMed

Insights

Improving intraoperative antibiotic redosing compliance through clear guidelines and electronic alerts significantly boosted adherence to 99%. This initiative also contributed to a reduction in surgical site infection rates.

Area of Science:

  • Healthcare Quality Improvement
  • Infectious Disease Management
  • Surgical Patient Safety

Background:

  • Unclear intraoperative antibiotic redosing guidelines led to 11% compliance and elevated surgical site infection (SSI) rates (3.19%) at Children's Hospital & Medical Center.
  • The hospital's SSI rate was significantly higher than the national benchmark of 1.87%.

Purpose of the Study:

  • Primary goal: Increase compliance with intraoperative antibiotic redosing protocols.
  • Secondary goal: Decrease the incidence of surgical site infections.

Main Methods:

  • Developed new organizational redosing guidelines based on Infectious Disease Society of America recommendations.
  • Implemented an antibiotic-specific reminder alert in the electronic medical record.
  • Conducted comprehensive education for anesthesiologists, surgeons, and nurses, with ongoing data evaluation and process updates.

Main Results:

  • Intraoperative antibiotic redosing compliance increased from 11% to a sustained average of 99%.
  • Provider knowledge of guidelines and processes improved.
  • Surgical site infection rates decreased from 3.19% to 2.3% between 2014 and 2018.

Conclusions:

  • Comprehensive education and electronic medical record alerts are effective in significantly improving intraoperative antibiotic redosing compliance.
  • Continuous education and regular process updates are crucial for sustaining improved compliance rates.
  • The interventions contributed to a reduction in surgical site infections, aligning with quality improvement goals.
Abstract

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