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Single-Nanoparticle Thermometry with a Nanopipette.

Martin Holub¹, Maria Adobes-Vidal², Andreas Frutiger¹

¹Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zurich, Zurich, CH-8092, Switzerland.

|May 20, 2020

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We developed a new nanothermometry technique for precise nanoscale temperature measurements in electrolyte solutions. This method enables sensitive detection of temperature changes with high spatial and temporal resolution, crucial for advanced technologies.

Area of Science:

Nanoscale science and technology
Physical chemistry
Materials science

Background:

Accurate nanoscale thermal measurements are vital for applications like drug delivery and photothermal therapies.
Existing techniques often lack the required spatial or temporal resolution for complex systems.

Purpose of the Study:

To present a novel nanothermometry technique for precise temperature mapping in electrolyte solutions.
To achieve high spatial resolution (nanoscale) and sensitivity (30 mK) with fast temporal response (43 μs).

Main Methods:

Utilizes ionic conductivity measurements confined to the tip of a nanopipette (as small as 6 nm opening).
Scans the nanopipette over a specimen, converting measured ion flux to temperature via theoretical modeling.
Applies to various capillary dimensions and substrates.

Keywords:

SICM finite element modeling functional scanning ion conductance microscopy nanoheater scanning probe microscopy

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Main Results:

Demonstrated simultaneous temperature and topography mapping on nanoparticle aggregates.
Observed micro- and nanobubble formation induced by plasmonic heating.
Achieved quantitative thermometry on individual 25 nm nanoheaters, showing temperature increases up to 3 K.

Conclusions:

The developed nanothermometry technique offers high precision and resolution for in vitro thermal measurements.
It is applicable to studying nanoscale thermal phenomena, such as those induced by plasmonic heating.
Enables quantitative thermal analysis at the single-nanoparticle level.