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Related Concept Videos

Overview of Microscopy Techniques01:22

Overview of Microscopy Techniques

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The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...
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Atomic Force Microscopy01:08

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Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
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Updated: Dec 21, 2025

Scanning-probe Single-electron Capacitance Spectroscopy
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Volcano-Shaped Scanning Probe Microscopy Probe for Combined Force-Electrogram Recordings from Excitable Cells.

B X E Desbiolles1, M T M Hannebelle2, E de Coulon3

  • 1Laboratory of Microsystems LMIS4, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.

Nano Letters
|May 20, 2020
PubMed
Summary
This summary is machine-generated.

Researchers developed a nanovolcano probe for simultaneous optical, force, and electrical measurements in mechanobiology. This novel instrument links mechanical stimuli to cellular electrophysiological responses, advancing single-cell studies.

Keywords:
Combined force-electrophysiological recordingsIon beam etching redepositionMechanobiologyNanovolcano probeNeonatal rat cardiomyocytesScanning probe microscopy

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Author Spotlight: Introduction to Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays
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Area of Science:

  • Biophysics
  • Cellular Mechanobiology
  • Nanotechnology

Background:

  • Atomic force microscopy advances mechanobiology but requires complementary techniques for physiological recording.
  • Linking mechanical cues to biological responses necessitates integrated measurement tools.

Purpose of the Study:

  • To present a novel instrument for combined optical, force, and electrical measurements.
  • To enable simultaneous recording of mechanical and electrical signals from single cells.

Main Methods:

  • Development of a scanning probe microscopy cantilever with a volcano-shaped nanopatterned microelectrode (nanovolcano probe).
  • Simultaneous force and electrical recordings using the nanovolcano probe.
  • Application to mechanically stimulated neonatal rat cardiomyocytes for impedance and extracellular field potential measurements.

Main Results:

  • Successful *in situ* impedance measurements on mechanically stimulated cardiomyocytes.
  • Simultaneous recording of extracellular field potentials (electrogram) and contraction displacement curves.
  • Demonstration of the nanovolcano probe's capability for integrated mechanobiological analysis.

Conclusions:

  • The nanovolcano probe facilitates combined mechanical and electrical measurements at the single-cell level.
  • This technology is well-suited for mechanobiological studies investigating the link between mechanical stimuli and electrophysiological responses.
  • Advances in single-cell analysis for understanding cellular mechanics and electrical activity.