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Follicular lymphoma genomics.

Lucy Pickard1, Giuseppe Palladino1, Jessica Okosun1

  • 1Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.

Leukemia & Lymphoma
|May 20, 2020
PubMed
Summary

Follicular lymphoma (FL) research reveals recurrent mutations in epigenetic regulators and the t(14;18) translocation. Understanding these genomic drivers offers new biomarkers and precision therapies for this incurable cancer.

Keywords:
Lymphomaclonal evolutionepigeneticsfolliculargenomicsheterogeneity

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Area of Science:

  • Hematology
  • Oncology
  • Genomics

Background:

  • Follicular lymphoma (FL) remains largely incurable despite improving outcomes.
  • The genomic landscape of FL is characterized by recurrent mutations in epigenetic regulators and the t(14;18) translocation.

Purpose of the Study:

  • To explore the genomic underpinnings of follicular lymphoma.
  • To identify novel biomarkers and therapeutic targets for FL management.

Main Methods:

  • Next-generation sequencing (NGS) was employed to analyze the genomic landscape of FL.
  • Longitudinal and spatially-derived lymphoma samples were studied to understand clonal evolution and heterogeneity.

Main Results:

  • Recurrent mutations in epigenetic regulators frequently co-occur with the t(14;18) translocation in FL.
  • Genomic studies revealed insights into tumoral heterogeneity and clonal evolution, supporting a tumor-repopulating cell population.

Conclusions:

  • In-depth understanding of FL genomics is crucial for identifying new biomarkers and therapeutic targets.
  • Genomic insights pave the way for precision-based management strategies in follicular lymphoma.