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Updated: Dec 21, 2025

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
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Dual Role of microRNAs in Autophagy of Colorectal Cancer

Tanu Sharma1, James A Radosevich2, Chandi C Mandal1

  • 1Department of Biochemistry, Central University of Rajasthan, Ajmer, Rajasthan, 305817, India.

Endocrine, Metabolic & Immune Disorders Drug Targets
|May 20, 2020
PubMed

Insights

MicroRNAs (miRNAs) regulate autophagy, a cellular process involved in cancer progression and metastasis. Targeting miRNAs offers a potential therapeutic strategy for colorectal cancer by modulating this pathway.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Autophagy is a conserved cellular degradation pathway crucial for cell survival.
  • Dysfunctional autophagy is implicated in cancer progression, adaptation, and metastasis, making it a therapeutic target.
  • MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression and play a dual role in colorectal cancer.

Purpose of the Study:

  • To elucidate the molecular mechanisms by which miRNAs regulate the dual role of autophagy in colorectal cancer.
  • To highlight the role of long noncoding RNAs (lncRNAs) in modulating miRNA expression and autophagy in colorectal cancer.

Main Methods:

  • Literature review and molecular pathway analysis.
  • Examination of miRNA-mRNA interactions in the context of autophagy.
  • Analysis of lncRNA-miRNA interactions influencing autophagy.

Main Results:

  • miRNAs exhibit context-dependent roles as tumor suppressors or promoters in colorectal cancer by regulating autophagy.
  • Dysregulation of autophagy by miRNAs contributes to cancer progression and metastasis.
  • lncRNAs can modulate miRNA expression, thereby influencing autophagy in colorectal cancer.

Conclusions:

  • miRNAs are key regulators of autophagy with a significant impact on colorectal cancer.
  • Targeting the miRNA-autophagy axis presents a promising therapeutic avenue for colorectal cancer treatment.
  • Understanding lncRNA-mediated regulation of miRNAs in autophagy is critical for developing novel cancer therapies.
Keywords:
Colorectal cancerautophagymicroRNAnon-coding RNAtumor promotertumor suppressor

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