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Updated: Dec 21, 2025

Peptide-based Identification of Functional Motifs and their Binding Partners
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Antiviral Peptides: Identification and Validation.

Garima Agarwal1, Reema Gabrani1

  • 1Department of Biotechnology, Center for Emerging Diseases, Jaypee Institute of Information Technology, Noida, UP 201309 India.

International Journal of Peptide Research and Therapeutics
|May 20, 2020
PubMed
Summary
This summary is machine-generated.

New peptide therapeutics offer a promising alternative to traditional antivirals, addressing resistance and side effects. Research explores diverse sources and advanced methods to identify effective peptide-based treatments for viral infections.

Keywords:
Binding evaluation techniquesHigh throughput screening methodsIn silico approachesPeptide based therapeutics

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Area of Science:

  • Biochemistry and Molecular Biology
  • Drug Discovery and Development
  • Virology

Background:

  • Viral infections pose significant global health challenges, with existing antiviral drugs facing limitations like resistance and adverse effects.
  • The development of novel antiviral strategies is crucial to combat increasing morbidity and mortality associated with viral diseases.
  • Peptide-based therapeutics represent an emerging and promising field for addressing these unmet needs in antiviral treatment.

Purpose of the Study:

  • To review and highlight the diverse sources and advanced methodologies employed in the identification of potential antiviral peptides.
  • To provide an overview of the current landscape of peptide-based antiviral therapeutics, including approved drugs and those in clinical trials.
  • To illustrate the application of cutting-edge techniques in evaluating the efficacy and binding characteristics of antiviral peptides.

Main Methods:

  • Literature review encompassing computational approaches, natural product screening, and high-throughput screening (HTS) for identifying lead antiviral peptides.
  • Exploration of advanced techniques from combinatorial chemistry and molecular biology for characterizing peptide-target interactions.
  • Analysis of existing data on approved peptide drugs and ongoing clinical trials for antiviral applications.

Main Results:

  • Over 60 peptide drugs are approved in major markets, with a growing number in clinical development.
  • Peptide therapeutics have demonstrated efficacy against viruses such as Human Immunodeficiency Virus (HIV), Influenza, and Hepatitis B and C.
  • Various sources, including natural and biological origins, coupled with computational methods, are effective in discovering potential antiviral peptides.

Conclusions:

  • Peptide-based therapeutics are a viable and expanding area for developing novel antiviral agents.
  • Advanced screening and characterization techniques are essential for identifying and optimizing peptide candidates for emerging viral infections.
  • Continued research into peptide sources and methodologies will drive the discovery of next-generation antiviral treatments.