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Cystatin C as an indicator of renal damage in pre-eclampsia
Hellen Cássia Dos Santos Gomes1, Antônio Carlos Vieira Cabral2, Silvia Passos Andrade3
1Department of Gynecology and Obstetrics, Federal University of Minas Gerais , Minas Gerais, Brazil.
Objective:
To assess the predictive abilities of serum and urinary cystatin C levels for glomerular lesions in pregnant women with pre-eclampsia.
Methods:
In this study, kidney function markers were compared between38 pregnant women with pre-eclampsia and 22 healthy pregnant women.
Results:
The serum and urine levels of cystatin C and urea were significantly higher in the pre-eclampsia group than in the control group. Receiver operating characteristic curve analysis demonstrated that the serum cystatin C level (91.7%) had a superior diagnostic accuracy for pre-eclampsia than the other markers.
Conclusion:
Serum cystatin C level maybe a significant marker of pre-eclampsia.
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