Provider Recommendations for Phase I Clinical Trials Within a Shared Decision-Making Model in Phase I Cancer Clinical...

Area of Science:

• Oncology
• Clinical Trials
• Shared Decision-Making

Background:

• Ongoing debate exists regarding the inclusion of explicit clinical trial recommendations in oncology shared decision-making.
• This study investigates how providers make recommendations for phase I cancer clinical trials.

Purpose of the Study:

• To determine if and how providers make explicit recommendations for phase I cancer clinical trials.
• To assess the alignment of these recommendations with shared decision-making frameworks.

Main Methods:

• Analysis of 23 patient/provider conversations regarding phase I trials.
• Interviews with 19 providers about their recommendation factors for phase I trials.

Main Results:

• Providers comprehensively consider factors like performance status (89%) and patient preferences (84%).
• Explicit recommendations were made in 83% of conversations, with 63% for phase I trials.
• Recommendations were consistent with shared decision-making in 95% of cases, often emphasizing patient opinion (58%).

Conclusions:

• Providers can confidently make explicit recommendations for phase I clinical trials.
• These recommendations can be integrated into shared decision-making processes effectively.
• Findings may extend to other clinical trial settings with further research.