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Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
Published on: May 6, 2020
State of the Art: Imaging of Osteoarthritis-Revisited 2020
Frank W Roemer1, Shadpour Demehri1, Patrick Omoumi1
1From the Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, FGH Building, 4th Floor, 820 Harrison Ave, Boston, MA 02118 (F.W.R., M.D.C., A.G.); Department of Radiology, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany (F.W.R.); Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md (S.D.); Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (P.O.); Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, Calif (T.M.L.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (R.K.); Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland (S.S.); Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland (S.S.); Institute of Sports Imaging, French National Institute of Sports (INSEP), Paris, France (M.D.C.); and Department of Radiology, VA Boston Healthcare System, Boston, Mass (A.G.).
Abstract:
Osteoarthritis (OA) is a highly prevalent chronic condition with marked implications for affected individuals and public health care. There are available treatments to manage pain and symptoms but no effective treatment for OA. In the past 10 years, joint imaging, particularly MRI, has evolved rapidly due to technical advances and their application to clinical research, which has led to abundant evidence regarding the natural history of the disease. Radiography remains the primary imaging modality in clinical practice for the diagnosis and follow-up of OA. The many developments in MRI techniques capable of assessing cartilage morphologic features and the methods for evaluating its biochemical composition will be discussed. Advances in quantitative morphologic cartilage assessment and semiquantitative whole-organ assessment will be reviewed, as will other modalities such as US, CT and CT arthrography, and nuclear medicine techniques that play a complementary role. Various therapeutic approaches and ongoing developments, including the impact of artificial intelligence on the field of OA imaging, will also be discussed.
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