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Urological malignancies in neurogenic patients
Bonnie Liu1, Blayne Welk1,2
1Department of Surgery.
Current Opinion in Urology
|May 20, 2020
Summary
Patients with neurogenic lower urinary tract dysfunction (NLUTD) have a lower incidence of bladder cancer but face higher mortality. Early recognition of genitourinary malignancies in NLUTD is crucial for improved patient outcomes.
Area of Science:
- Urology
- Oncology
Background:
- Neurogenic lower urinary tract dysfunction (NLUTD) affects patients with various neurological conditions.
- Genitourinary malignancies are a significant concern in this population.
Purpose of the Study:
- To review recent literature on urologic malignancies in patients with NLUTD.
- To synthesize current findings on bladder, prostate, and renal cancers in NLUTD patients.
Main Methods:
- Literature search of electronic databases (PubMed, ScienceDirect, Scopus, CIANHL).
- Focus on articles published between January 2015 and December 2019.
Main Results:
- Bladder cancer incidence in NLUTD is lower than previously thought but higher than the general population.
- Bladder cancer in NLUTD presents at a younger age, with higher rates of squamous cell carcinoma, advanced stage, and mortality.
- Conflicting evidence exists for bladder cancer screening protocols in NLUTD.
- NLUTD may be associated with lower prostate cancer rates and earlier renal cancer diagnosis.
Conclusions:
- Genitourinary malignancies, while rare, contribute to morbidity and mortality in NLUTD patients.
- Bladder cancer in NLUTD is often aggressive and lethal.
- Further research is needed for early detection and improved outcomes.
