Rescue therapy for severe COVID-19-associated acute respiratory distress syndrome with tissue plasminogen activator:...

Christopher D Barrett¹, Achikam Oren-Grinberg, Edward Chao+13

• ¹From the Division of Acute Care Surgery (C.D.B., R.J., M.B.Y.), Trauma and Surgical Critical Care, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; Departments of Biological Engineering and Biology (C.D.B., M.B.Y.), Koch Institute for Integrative Cancer Research, Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge; Department of Anesthesia (A.O.-G., A.M.I., M.L.K., D.S.T., S.S.), Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Division of Trauma and Surgical Critical Care (E.C., S.H.R., M.U.), Department of Surgery, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, New York; Division of Pulmonary and Critical Care (A.H.M.), Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts; Department of Surgery (M.J.M.), Scripps Mercy Hospital, San Diego, California; Department of Emergency Medicine (A.M.I.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Department of Surgery (H.B.M., E.E.M.), University of Colorado Denver, Aurora; Department of Surgery (E.E.M.), Ernest E Moore Shock Trauma Center at Denver Health, Denver, Colorado; Division of Pulmonary, Critical Care and Sleep Medicine (E.N.B.-K.), Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.