Related Experiment Video
Updated: Dec 21, 2025
09:01
Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
Published on: January 27, 2023
2.0K
MicroRNAs-containing extracellular vesicles in bone remodeling: An emerging frontier
Xinqi Huang1, Xiner Xiong2, Jun Liu1
1Department of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Life Sciences
|May 20, 2020
Summary
Extracellular vesicles (EVs) carrying microRNAs (miRNAs) facilitate cell communication in bone remodeling. This intercellular signaling regulates bone health and offers potential for new therapies.
Area of Science:
- Cell Biology
- Biochemistry
- Regenerative Medicine
Background:
- Bone remodeling is a continuous process regulated by cellular communication.
- Extracellular vesicles (EVs) transport functional molecules between cells.
- MicroRNAs (miRNAs) are key regulators of gene expression.
Purpose of the Study:
- To review the role of EV-delivered miRNAs in intercellular communication during bone remodeling.
- To explore the involvement of EVs and miRNAs in signaling pathways affecting bone cells.
- To highlight the therapeutic and diagnostic potential of EV-miRNAs in bone diseases.
Main Methods:
- Literature review of studies on extracellular vesicles and microRNAs in bone biology.
- Analysis of the mechanisms by which EVs transport miRNAs.
- Examination of the impact of EV-miRNAs on mesenchymal stem cells, osteoblasts, osteoclasts, osteocytes, and myoblasts.
Main Results:
- EVs act as crucial mediators for transferring miRNAs between bone cells.
- EV-miRNAs modulate signaling pathways essential for bone homeostasis.
- Specific EV-miRNA interactions influence the behavior of bone-related cells.
Conclusions:
- EV-miRNAs are vital for intercellular communication in the bone microenvironment.
- Understanding EV-miRNA functions can advance tissue engineering strategies for bone repair.
- EV-miRNAs represent promising diagnostic markers and therapeutic targets for bone disorders.
More Related Videos
Related Concept Videos
01:31Osteoclasts in Bone Remodeling
3.7K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.7K
01:40Bone Remodeling
40.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.1K
01:29The Extracellular Matrix
11.6K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
11.6K
01:42The Extracellular Matrix
87.8K
Overview
87.8K
01:18The Bone Matrix
5.3K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.3K
01:15Receptor Downregulation in MVBs
2.7K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.7K