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Updated: Dec 21, 2025
05:16
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
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The association between adenomyosis and recurrent miscarriage
Cem Somer Atabekoğlu1, Yavuz Emre Şükür1, Erkan Kalafat1
1Ankara University School of Medicine, Department of Obstetrics and Gynaecology, Ankara, Turkey.
Summary
Ultrasonographic adenomyosis was significantly more prevalent in women experiencing recurrent miscarriage (RM). Adenomyosis is a key risk factor for RM, alongside uterine anomalies.
Area of Science:
- Reproductive Medicine
- Gynecologic Imaging
- Women's Health
Background:
- Recurrent miscarriage (RM) poses a significant challenge in reproductive medicine.
- Identifying underlying causes of RM is crucial for effective management.
- Adenomyosis, a condition characterized by endometrial tissue within the myometrium, is increasingly recognized as a potential contributor to reproductive failure.
Purpose of the Study:
- To investigate the association between ultrasonographically diagnosed adenomyosis and the occurrence of recurrent miscarriage.
- To compare the prevalence of adenomyosis in women with RM versus controls without RM.
Main Methods:
- A prospective, matched case-control study involving 132 women.
- Transvaginal ultrasonography was used to identify adenomyosis markers.
- Cases comprised 66 women with RM; controls were 66 women without RM or other gynecologic conditions.
Main Results:
- Ultrasonographic adenomyosis was significantly more frequent in the recurrent miscarriage group (19.7%) compared to controls (6.1%; P = 0.035).
- Heterogeneous myometrium was the most common ultrasonographic finding in women with RM (18.2%).
- Adenomyosis or other risk factors were identified in 63.6% of women with RM.
Conclusions:
- The study demonstrates a significantly higher prevalence of adenomyosis in women with recurrent miscarriage.
- Adenomyosis and uterine anomalies are identified as the most common risk factors associated with recurrent miscarriage.
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