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An HFAC block-capable and module-extendable 4-channel stimulator for acute neurophysiology
Adrien Rapeaux1, Timothy G Constandinou
1Centre for Bio-Inspired Technology, Imperial College London , London, SW7 2AZ, United Kingdom. Department of Electrical and Electronic Engineering, Imperial College London, London, SW7 2BT, United Kingdom. Care Research & Technology Centre, UK Dementia Research Institute at Imperial College London, London, United Kingdom. Author to whom any correspondence should be addressed.
This study presents a novel, affordable multichannel stimulator for neurophysiology experiments. The device enables simultaneous nerve excitation and inhibition, advancing selective neural interfacing techniques.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Instrumentation
Background:
- Experimental neurophysiology often demands costly and bulky equipment.
- Existing stimulators have limited inter-device communication, complicating complex protocols.
- High-frequency alternating current (HFAC) block requires specialized, often expensive, apparatus.
Purpose of the Study:
- To design and test a novel multichannel block-capable stimulator for acute neurophysiology.
- To enable highly selective neural interfacing techniques.
- To provide an affordable, portable, and space-saving solution for nerve stimulation and blocking.
Main Methods:
- The stimulator utilizes a Howland Current Pump circuit and an ARM Cortex-M4 Microcontroller.
- It features 4 independently driven current output channels with ±10 mA output and ±15 V compliance.
- Programmable operation allows for monophasic, biphasic, and high-frequency alternating current (HFAC) stimulation.
Main Results:
- The device achieves ±10 mA output current with ±15 V compliance and high resolution (<6 µA).
- It successfully demonstrated concurrent excitation and inhibition of nerve activity in a rat sciatic nerve model.
- The stimulator is compact (9 cm × 6 cm × 5 cm) and built from COTS components for under $450.
Conclusions:
- This novel stimulator offers an effective, affordable, and portable solution for multi-channel nerve stimulation and block.
- It facilitates advanced studies in selective neural interfacing for acute neurophysiology experiments.
- Open-source availability of design files encourages community use and further development.
