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Published on: November 5, 2016
Cardioprotective effects of GLP-1(28-36a): A degraded metabolite or GLP-1's better half?
Yangyang Liu1, Sodai Kubota1,2, Katsumi Iizuka1
1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan.
Abstract:
Molecular mechanism underlying glucagon-like peptide-1 exertion of cardioprotective effects in glucagon-like peptide-1 receptor-dependent and -independent manners. Glucagon-like peptide-1 (28-36a) enters coronary artery endothelial cells through macropinocytosis and binds to mitochondrial trifunctional protein-α, shifting substrate utilization to increase adenosine triphosphate production and modulating a adenosine triphosphate-sensor soluble adenylyl cyclase, thereby producing cyclic adenosine monophosphate and activating protein kinase A to exert cytoprotection from oxidative injury.
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