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Hematological Diseases and Osteoporosis.
Agostino Gaudio1, Anastasia Xourafa1, Rosario Rapisarda1
1Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
International Journal of Molecular Sciences
|May 21, 2020
Summary
Secondary osteoporosis, often seen in men, can stem from hematological diseases like multiple myeloma. Integrated care with bone specialists may reduce fractures and improve patient quality of life.
Area of Science:
- Bone health and osteoporosis research
- Hematology and internal medicine
Background:
- Secondary osteoporosis is a significant clinical issue, more prevalent in men.
- Hematological diseases represent a key cause of secondary osteoporosis, impacting bone health.
- Conditions such as multiple myeloma, thalassemia, hemophilia, and sickle cell disease are linked to skeletal complications.
Purpose of the Study:
- To review the impact of hematological diseases on bone health.
- To highlight the role of cytokines in the pathogenesis of bone loss.
- To emphasize the importance of an integrated approach involving bone specialists.
Main Methods:
- Literature review of studies on hematological diseases and bone health.
- Analysis of pathogenetic mechanisms, including the role of cytokines.
- Discussion of clinical implications and management strategies.
Main Results:
- Multiple myeloma, systemic mastocytosis, thalassemia, hemophilia, and sickle cell disease are associated with bone abnormalities.
- Monoclonal gammopathy of undetermined significance is increasingly recognized as a risk factor for fractures, particularly in males.
- Cytokines regulating bone metabolism are implicated in the bone loss associated with these conditions.
Conclusions:
- Hematological diseases significantly contribute to secondary osteoporosis, especially in men.
- Understanding the role of cytokines is crucial for elucidating bone loss mechanisms.
- A collaborative approach between hematologists and bone specialists can mitigate fracture risk and enhance patient outcomes.
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