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Related Experiment Videos

Phase behaviour of lipid X.

G Lipka1, R A Demel, H Hauser

  • 1Laboratorium fuer Biochemie, Eidgenoessische Technische Hochschule, Zuerich, Switzerland.

Chemistry and Physics of Lipids
|October 1, 1988
PubMed
Summary

Lipid X forms disk-shaped micelles in aqueous solutions, influencing bacterial lipopolysaccharide structure. Its aggregation behavior is sensitive to pH and salt concentration, crucial for understanding biological membranes.

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Area of Science:

  • Biochemistry
  • Physical Chemistry
  • Lipid Science

Background:

  • Lipid X is a precursor to bacterial lipopolysaccharides.
  • Understanding its phase behavior is key to elucidating lipopolysaccharide structure and function.

Purpose of the Study:

  • To investigate the phase behavior of aqueous dispersions of lipid X.
  • To characterize the aggregation state and molecular properties of lipid X.

Main Methods:

  • Physico-chemical techniques were employed.
  • Monolayer studies were conducted.
  • Phase behavior was analyzed under varying conditions (pH, ionic strength).

Main Results:

  • Lipid X forms disk-shaped micelles (13 +/- 1.8 nm diameter) in aqueous and saline solutions.
  • Critical micellar concentration is 4 x 10(-5) M.
  • Lipid X exhibits a wedge-like shape with mobile hydrocarbon chains in micelles, distinct from bilayers.

Conclusions:

  • Lipid X forms micelles with specific packing and dynamics.
  • Its aggregation state is dependent on pH, ionic strength, and counterion type.
  • The findings provide insights into the structural properties of lipid X relevant to bacterial membranes.

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