Multivalent manganese complex decorated amphiphilic dextran micelles as sensitive MRI probes
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Updated: Dec 21, 2025

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Changqiang Wu1, Danyang Li, Li Yang
1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P. R. China. huaai@scu.edu.cn.
Abstract:
T1 contrast agents based on Mn(II) were conjugated on amphiphilic dextran micelles via click chemistry. The obtained paramagnetic nanomicelle contrast agent has a higher T1 relaxivity (13.3 Mn mmol-1 s-1) and better sensitivity than those of free Mn(II) complexes. Studies carried out in vivo suggest that this contrast agent has a better and long-acting vascular enhancement effect at a lower manganese dosage (0.1 Mn mmol kg-1 BW).

